izindaba

I-granulator eyomile iyindlela entsha ye-granulation ethuthukiswe ngemuva kwe- "one-step-granulation" yendlela yesizukulwane sesibili ye-granulation. Kuyinqubo ye-granulation enobungani bemvelo kanye nemishini emisha yokucindezela i-powder ngqo kuma-granules. I-granulator eyomile isetshenziswa kabanzi ezimbonini zemithi, ukudla, amakhemikhali nezinye izimboni, ikakhulukazi ezifanele i-granulation yezinto ezilula ukubola noma ukuhlangana lapho zimanzi futhi zishisa. Ama-granules enziwe yi-granulator eyomile angacindezelwa ngqo kumathebulethi noma afakwe kumaphilisi.

Ekwenziweni kwemithi yamaShayina neyaseNtshonalanga, i-granulator idlala indima ebaluleke kakhulu. Ngokuthuthuka okuqhubekayo kwemakethe yezemithi yokwelashwa, okulindelwe nezidingo zabantu embonini yezemithi nakho kuphakeme kakhulu. Uma i-granulator ifuna ukuba nentuthuko engcono ngokuzayo, kufanele iqhubeke nokwenza imikhiqizo emisha ngezinguquko zemakethe.

Ngokuzayo, izofinyelela izidingo zenhlanzeko nokuguquguquka kokusebenza. Okokuqala, uhlelo oluvalwe ngokuphelele lwe-granulation lunganciphisa ukungcola kothuli enqubweni yokukhiqiza, ukuze kuncishiswe ukungcola kanye nengozi yokungcola; Okwesibili, imishini isebenzisa ukwakheka kwe-modular, yonke idivayisi ye-granulating ingahlukaniswa ngamathuluzi ambalwa kuphela, okulungele ukuhlanza wonke amayunithi we-module, futhi i-screw kanye ne-roller roller ingashintshwa kalula ukuze ivumelane nemisebenzi ehlukahlukene ye-granulating.

Umshini usetshenziselwa ukwenza impuphu eyomile ibe yimishini ethile yokuhlola ubukhulu nobukhulu bezinhlayiyana, enikeza izinhlayiya ezinhle zoketshezi lokwenza ithebhulethi nemishini yokugcwalisa i-capsule. Isetshenziswa kakhulu ocwaningweni nasekuthuthukisweni kwamafomu amasha wokulinganisa nokukhiqizwa kwamalungiselelo amancane nama-API. Ukunikeza ama-granules nge-fluidity enhle yokwenza ithebhulethi nemishini yokugcwalisa i-capsule. Umkhiqizo uhlangabezana nezidingo ze-GMP zokukhiqiza izidakamizwa.
I-granulation eyomile inezinzuzo zenqubo elula, ukusetshenziswa kwamandla okuphansi nokuxhumeka okulula nenqubo ekhona. Uma kuqhathaniswa ne-granulation emanzi, inezinzuzo zesidingo se-binder ne-solvent, futhi azikho izinkinga zokushisa okuphezulu nokubuyiselwa kwe-solvent. Inqubo ye-granulation ingaqedwa ngokudla okukodwa, okusindisa abasebenzi abaningi nendawo yaphansi.


Isikhathi Iposi: Jul-06-2021